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HUMAN UROTHELIAL CELL SPECIFIC UROPLAKIN TRANSCRIPTIONAL REGULATORY SEQUENCES, VECTORS COMPRISING THE SAME, AND METHODS OF USE THEREOF
HUMAN UROTHELIAL CELL SPECIFIC UROPLAKIN TRANSCRIPTIONAL REGULATORY SEQUENCES, VECTORS COMPRISING THE SAME, AND METHODS OF USE THEREOF
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机译:人尿道上皮细胞特定的尿蛋白转录调控序列,包含其的载体及其使用方法
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摘要
The invention provides new urothelial cell specific transcriptional regulatory sequences derived from human uroplakin II (hUPII), as well as polynucleotide constructs such as adenoviral vectors and methods of using hUPII-derived TREs. Additionally, the invention provides adenoviral vectors comprising a gene, preferably an adenovirus gene, under transcriptional control of a urothelial cell-specific transcriptional regulatory element (TRE). These vectors display urothelial cell-specific cytotoxicity, which is especially useful in the context of bladder cancer, in which destruction of these cells is desirable. The invention further provides compositions and host cells comprising the vectors, as well as method of using the adenoviral vectors.
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