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SHORT POLYPEPTIDE MEDIATED CONFORMATIONAL CHANGES PROMOTING ENHANCEMENT OF ENZYMATIC ACTIVITY
SHORT POLYPEPTIDE MEDIATED CONFORMATIONAL CHANGES PROMOTING ENHANCEMENT OF ENZYMATIC ACTIVITY
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机译:短肽介导的构象变化,促进酶活性的增强
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摘要
The invention provides for an isolated and purified tagged dimeric protein as well as a process for producing and purifying the same and the use thereof. The present invention also relates to methods and pharmaceutical compositions for the treatment of lysosomal storage diseases. More specifically the invention provides methods and compositions for treating sulfatase deficiency. In particular, the invention relates to methods and compositions for treating sulfatase deficiency diseases caused all or in part by deficiencies in human N-acetylgalactosamine-6-sulfatase (GALNS) including mucopolysaccharidosis IVA (MPS IVA).
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