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DETECTION OF CANCER BY MEASURING GENOMIC COPY NUMBER AND STRAND LENGTH IN CELL-FREE DNA
DETECTION OF CANCER BY MEASURING GENOMIC COPY NUMBER AND STRAND LENGTH IN CELL-FREE DNA
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机译:通过检测无细胞DNA中的基因拷贝数和链长来检测癌症
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摘要
The present invention relates, e.g., to a method for diagnosing a cancer in a subject, comprising measuring in a cell-free body fluid of the subject a) the amount of DNA in the body fluid from an amplified cancer-associated chromosomal locus, compared to a positive and/or a negative reference standard, wherein the positive and negative standards reflect the amount of the DNA in the body fluid of a subject having the cancer, or not having the cancer, respectively, and b) the strand length integrity index of the DNA in the body fluid from the amplified cancer-associated chromosomal locus compared to a baseline value, wherein if the amount of the measured DNA is statistically significantly increased compared to the negative reference standard, and/or is statistically the same as the positive reference standard, and if the strand length integrity index is at least about 0.65, this is indicative that the subject has the cancer.
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