CORE-SHELL MACROMOLECULES FOR SPECIFIC CELL NUCLEUS OR/AND CELL MATRIX STAINING

摘要

Water-soluble fluorescent core-shell macromolecules containing multiple carboxylic acid groups were synthesized via ATRP by applying perylenediimide derivatives as template. These compounds show high fluorescence quantum yields and photostability in water. Histochemistry and dot blotting experiments show that these macromolecules specifically and rapidly stain the cell nucleus by interaction with histones. Due to their spectral properties, these compounds offer an attractive alternative to existing fluorescent staining methods.