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DETERMINATION OF BONE-SIALOPROTEIN IN BODILY FLUIDS FOR ONCOLOGICAL PROBLEMS
DETERMINATION OF BONE-SIALOPROTEIN IN BODILY FLUIDS FOR ONCOLOGICAL PROBLEMS
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机译:人体疾病中骨唾液蛋白的测定
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摘要
The invention relates to antibodies or a plurality of antibodies against human bone sialoprotein (BSP), characterized in that the antibodies bind to epitopes which are present only in human bone sialoprotein from tumor cells, the post-translational glycosylation of which is modified or incomplete in the region of amino acids of 120 to 135, containing the amino acids TGLAA (SEQ ID NO: 2), in comparison with normal bone sialoprotein from bones. The antibodies are put to use in an immunoassay for the diagnosis and prognosis of tumor diseases, in particular the diagnosis and prognosis of bone metastases in the case of primary breast carcinoma.
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机译:本发明涉及抗人骨唾液蛋白(BSP)的抗体或多种抗体,其特征在于所述抗体结合仅存在于来自肿瘤细胞的人骨唾液蛋白中的表位,其翻译后糖基化被修饰或不完整。与来自骨骼的正常骨唾液蛋白相比,包含氨基酸TGLAA(SEQ ID NO:2)的120至135个氨基酸区域。该抗体用于免疫测定以诊断和预后肿瘤疾病,特别是原发性乳腺癌的骨转移瘤的诊断和预后。
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