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TOXOPLASMA GONDII MUTANT WITH ENHANCED HOMOLOGOUS RECOMBINATION AND USES THEREOF

机译：弓形虫重组增强型弓形虫突变体及其用途

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摘要

The present invention relates to a mutant Toxoplasma gondii which exhibits enhanced homologous recombination. The mutant of the present invention is a knockout in the KU80-dependent nonhomologous end-joining pathway which finds application in generating T. gondii gene knockouts and gene replacements for use in vaccine and drug development.

机译：本发明涉及表现出增强的同源重组的突变体弓形虫。本发明的突变体是依赖于KU80的非同源末端连接途径中的敲除，该途径可用于产生弓形虫基因敲除和用于疫苗和药物开发的基因替代。

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公开/公告号WO2009058712A1

专利类型
公开/公告日2009-05-07

原文格式PDF
申请/专利权人 TRUSTEES OF DARTMOUTH COLLEGE;BZIK DAVID J.;FOX BARBARA A.;
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申请/专利号WO2008US81274
发明设计人 FOX BARBARA A.;BZIK DAVID J.;
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申请日2008-10-27
分类号C12N1/10;
国家 WO
入库时间 2022-08-21 19:18:58

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