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TRANSDERMAL DRUG DELIVERY SYSTEM OF STRYCHNINE, BRUCINE, SECURININE AND THEIR SALTS
TRANSDERMAL DRUG DELIVERY SYSTEM OF STRYCHNINE, BRUCINE, SECURININE AND THEIR SALTS
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机译:士的宁,精氨酸,司汀和其盐的经皮药物输送系统
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摘要
Strychnine, brucine (A) and securinine (B) are a group of natural drugs for central excitation. Because their oral dose or injection dose is close to the half lethal dose, the drugs, with a great toxic side effect, may be lethal if improperly used. The invention is characterized by using the transdermal drug delivery system as a substitute for the oral or injection dosage form to directly act on the local nervous system through the skin, avoiding the toxic side effect caused by drugs directly entering the blood circulating system. The dose through cutaneous absorption is far lower than the oral or injection dose, so it has a much higher safety and a longer acting effect. The transdermal drug delivery system is useful for the treatment of central or peripheral neural paralysis and other nervous system related diseases.
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