A NOVEL BIOLOGICAL CANCER MARKER AND METHODS FOR DETERMINING THE CANCEROUS OR NON-CANCEROUS PHENOTYPE OF CELLS

摘要

The present invention relates to the use of the frequency value of filopodia generation in a sample cell population as a biological marker for determining the cancerous, metastatic cancerous or normal phenotype of said cell population. It also relates to a method for determining in vitro the cancerous, metastatic cancerous or normal phenotype of cells contained in a sample, wherein said method comprises a step of in vitro measuring the frequency of filopodia generation in the cells contained in the sample. The present invention further concerns methods for the screening of the carcinogenic properties of a compound or of the metastatic properties of a compound which make use of the general method described above.