Antiandrogen oligonucleotides usable for the treatment of dermatological androgen-related disorders relating to androgen metabolism, their pharmaceutical compositions, their uses and treatment method

摘要

Antiandrogen oligonucleotides suitable for the treatment of hair loss and androgen-metabolism related skin disorders, are described. The oligonucleotides have the following sequences: IMAGE IMAGE IMAGE IMAGE IMAGE IMAGE IMAGE IMAGE ??These anti-androgenic active principles are very specific to reach their molecular target, which is especially circumscribed to the site of application, mainly the human androgen receptor in treated human skin and scalp. The oligonucleotides described inhibit the androgen receptor (AR) expression at very low concentrations in skin and hair follicle primary cell cultures, through a mechanism implying the reaching of, and the hibridizing with, specific regions of the AR mRNA, thereby triggering the RNAse H digestion of the AR mRNA and thus inhibiting the AR translation. ??Pharmaceutical or cosmetic, or both, compositions that may be topically administered and contain the oligonucleotides, as well as the use of anti - androgen oligonucleotides and a treatment methods are described too.