ANIMALS OF THE RATTUS GENUS WHEREIN MSH6 EXPRESSION IS FUNCTIONALLY DECREASED AND METHODS FOR THE GENERATION OF SPECIFIC MUTANTS THERE FROM

摘要

The invention relates to methods for producing an animal of the genus rattus having a functionally reduced mshϑ expression in a germ line cell with a mutagen induced mutation in said germ line cell. The invention further relates to specific uses of an animal of the genus rattus in which mshϑ expression is functionally decreased and to an animal with a mutagen induced mutation and a collection of germ-line cells or derivatives thereof of said animal.