ULTRA LOW STRENGTH ELECTRIC FIELD NETWORK-MEDIATED EX VIVO GENE, PROTEIN AND DRUG DELIVERY IN CELLS

摘要

Ex vivo gene, protein or drug delivery to macroscopic quantities of various types of cells, cell clusters, or tissues using ultra low strength LSEFN strategies is disclosed in which the bioengineered cells and tissues are then systemically transfused, delivered or implanted into the various organs or tissue for the treatment of diseases. An LSEFN chamber is used which is shaped and sized to intimately contain the cells, cell clusters, or tissues in a transfusion chamber between opposing membrane encapsulated electrode arrays across which LSEFN pulses are applied.