EPIGENETIC SILENCING OF MIR-342 IN COLORECTAL CANCER

摘要

Novel tools and methods for the detection and treatment of colorectal cancer are provided. Expression of miR-342 and/or EVL are reduced or absent in colorectal cancer, due to methylation-induced silencing. Detection of specific methylation of the EVL gene is provided as a method for detecting the presence or risk of colorectal cancer. Therapeutic administration of miR-342 and/or EVL and/or administration of demethylation agents to restore activity of miR- 342 and EVL are provided as methods for treating or preventing colorectal cancer.