TUMOR-ASSOCIATED BIOMARKERS FROM THE DARK PROTEOM

摘要

Pancreas cancer often goes undetected until late stage disease. Unlike prostate and ovarian cancer, no markers are available to detect pancreas cancer in earlier stages of disease. Plasma is a convenient source to detect potential biomarkers for cancer because individuals provide peripheral blood for other routine clinically indicated tests. In one embodiment, the present invention identifies peptides that are present in pancreas cancer patient plasma samples that are not present in plasma from normal donors using nanospray ion trap LC- MS/MS methods.