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Optical detection apparatus based on phase-shift interferometry
Optical detection apparatus based on phase-shift interferometry
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机译:基于相移干涉术的光学检测装置
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摘要
Apparatus and method for detecting the presence or amount or rate of binding of an analyte in a sample solution is disclosed. The apparatus includes an optical assembly having first and second reflecting surfaces separated by a distance "d" greater than 50 nm, by a transparent material where the first surface is formed by a layer of analyte-binding molecules, and a light source for directing a beam of light onto said first and second reflecting surface. A detector in the apparatus operates to detect a change in the thickness of the first reflecting layer resulting from binding of analyte to the analyte-binding molecules, when the assembly is placed in the solution of analyte, by detecting a shift in phase of light waves reflected from the first and second surfaces. The second reflecting surface comprises a layer of material having a refractive index greater than the refractive index of the transparent material.
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