A DNA VACCINE FOR CURING CHRONIC HEPATITIS B AND A METHOD OF PREPARING SAME

摘要

The present invention relates to a DNA vaccine that can effectively induce immune responses specific to multiple antigens for treating chronic Hepatitis B, and to a method for preparing the DNA vaccine, wherein said DNA vaccine comprises antigenic genes encoding hepatitis B surface antigen (HBsAg), an L protein, a core, and a polymerase, and preferably further IL-12 variant as an adjuvant. The antigenic genes of said vaccine enhance the expression of antigens through codon-optimization, and effectively induce antibody responses specific to antigen used and cell-mediated immune responses. Accordingly, the DNA vaccine of the invention can be effectively used for curing chronic Hepatitis B.