AMBRISENTAN COMBINED WITH A RENIN INHIBITOR FOR HYPERTENSIVE DISORDER

摘要

Therapeutic combinations and pharmaceutical compositions are provided comprising ambrisentan and an inhibitor of renin activity or release. Such combinations and compositions are useful to treat hypertensive disorders, particularly pulmonary hypertension conditions such as pulmonary arterial hypertension, to prevent cardiovascular adverse events related thereto, to enhance pulmonary function and to extend time to clinical worsening in a subject having a pulmonary hypertension condition.