PROCESS AND APPARATUS FOR INTRODUCTION OF GAS INTO AND DEGASSING OF LIQUIDS, IN PARTICULAR IN BIOTECHNOLOGY AND ESPECIALLY OF CELL CULTURES

摘要

The invention relates to a process and an apparatus for the bubble-free production of gas into liquids, in particular in biotechnology and especially of cell cultures, with gas exchange via one or more immersed membrane areas of any type (tubes, cylinders, etc), with the membrane area forming any rotary oscillating motion in the liquid, which solves the problem addressed. Fig. 1 schematically shows an example of such an arrangement and motion, with the membrane area in this case being formed by membrane tubes (1) which are arranged on a rotor shaft (2) vertically and perpendicular to the direction of rotation (3). In the case of a rotary oscillating motion, the membrane area moves firstly in one direction of rotation, with the motion being able to be configured in any way. An example is acceleration of the membrane area with a particular angular acceleration up to a particular angular velocity with which the membrane area then moves for a particular time. The membrane area is subsequently braked with a fixed delay until it stops. Subsequently, if appropriate after a fixed stationary time, the membrane area moves in the other direction of rotation. This motion can be a mirror image of that described above or can be configured differently.