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all body cells of patients with mitochondrial and nuclear DNA cloning embryonic stem cell -derived cells for therapy mainly from DNA how to match .

机译:线粒体患者的全身细胞和核DNA克隆胚胎干细胞衍生的细胞主要用于治疗从DNA到细胞的匹配。

摘要

A method for conforming nuclear DNA and mitochondrial DNA of a treating cell derived for body cell and reproduction embryonic stem cell line of patient is provided to raise the rate of success for reproduction embryonic stem cell line by collecting cell of the child and mother ovum in advance. A realization method of a treating cell derived with the normal patient customized reproduction embryonic stem cell line is realized by using ovum of the human, ovum provider and the other's somatic cell. A method for conforming nuclear DNA and mitochondrial DNA of a treating cell derived for body cell and reproduction embryonic stem cell line of patient, comprises a step for replacing the necleus of the mother ovum of the young age with the necleus of the somatic cell of the young child to make the reproduction embryo bud; a step for making a reproduction embryonic stem cell and a treating cell by using it; and a step for conforming nuclear DNA and mitochondrial DNA of a treating cell derived for body cell and reproduction embryonic stem cell line of patient when the child turns patient in future.
机译:提供了一种使源自患者的体细胞和生殖胚胎干细胞系的治疗细胞的核DNA和线粒体DNA相一致的方法,以通过预先收集子卵和母卵细胞来提高生殖胚胎干细胞系的成功率。 。通过使用人的卵子,卵子提供者和其他人的体细胞来实现由正常患者定制的生殖胚胎干细胞系衍生的治疗细胞的实现方法。用于使源自患者的体细胞和生殖胚胎干细胞系的治疗细胞的核DNA和线粒体DNA相吻合的方法,其包括用幼体的体细胞核替换年轻的卵子的核的步骤。年幼的孩子使生殖胚胎发芽;通过使用其制备生殖胚胎干细胞和处理细胞的步骤;以及当孩子将来变成病人时,使来源于病人的身体细胞和生殖胚胎干细胞系的治疗细胞的核DNA和线粒体DNA相一致的步骤。

著录项

  • 公开/公告号KR20080111749A

    专利类型

  • 公开/公告日2008-12-24

    原文格式PDF

  • 申请/专利权人 KIM KYUNG HEE;

    申请/专利号KR20070060077

  • 发明设计人 KIM KYUNG HEE;

    申请日2007-06-19

  • 分类号C12N5;C12N5/08;C12N5/02;

  • 国家 KR

  • 入库时间 2022-08-21 19:14:28

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