FAM83H GENE FOR DENTAL ENAMEL CALCIFICATION

摘要

A pharmaceutical composition containing FAM83H(family with sequence similarity 83, member H) or mammal homologs protein is provided to treat dominant hypocalcification type amelogenesis imperfecta by adjusting action of a selected gene related to the dominant hypocalcification type amelogenesis imperfecta. A pharmaceutical composition contains normal FAM83H(family with sequence similarity 83, member H) or mammal homologs protein. The mammal represents rat, rabbit, pig, cow, monkey, goat or cat. The normal FAM83H has amino acid sequence indicated as sequence number 62. The mammal homologs protein has greater than 70% of similarity with the amino acid sequence indicated as sequence number 62. The pharmaceutical composition is administered to patients in order to treat the dominant hypocalcification type amelogenesis imperfecta.