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A COMPOSITION FOR PREVENTING OR TREATING ARTERIOSCLEROSIS COMPRISING SAXATILIN, A SNAKE VENOM DISINTEGRIN
A COMPOSITION FOR PREVENTING OR TREATING ARTERIOSCLEROSIS COMPRISING SAXATILIN, A SNAKE VENOM DISINTEGRIN
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机译：一种预防或治疗动脉硬化症的药物组合物，该药物包含沙沙汀，蛇毒崩解素
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摘要
A composition for preventing or treating arteriosclerosis comprising saxatilin which is a snake venom-derived disintegrin is provided to prevent the adhesion and movement within a blood vessel endothelial cell of monocyte and macrophages in an arteriosclerosis initial step. A composition for preventing or treating arteriosclerosis comprises saxatilin as an active ingredient. The saxatilin is separated from the venom of Agkistrodon saxatilis emelianov and has an amino acid sequence listed in SEQ ID NO: 1. The saxatilin is the recombination saxatilin protein separated from Pichia pastoris Y/pPSAX KCCM-10201.
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机译：提供了一种预防或治疗动脉硬化的组合物，其包含萨沙替林，它是蛇毒衍生的整联蛋白，以防止在动脉硬化初始步骤中单核细胞和巨噬细胞在血管内皮细胞内的粘附和运动。预防或治疗动脉硬化的组合物包含萨沙替林作为活性成分。萨克萨提林与Agxistrodon saxatilis emelianov的毒液分离，并具有SEQ ID NO：1中列出的氨基酸序列。萨克萨林是从巴斯德毕赤酵母Y / pPSAX KCCM-10201分离的重组萨克萨林蛋白。
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