NANO-PARTICLES FOR TARGETING COMPRISING HYALURONIC ACID OR ITS SALT, METAL ION, AND WATER-INSOLUBLE BIODEGRADABLE POLYMER AND PROCESSES FOR THE PREPARATION THEREOF

摘要

Millimicro particle is provided to the release speed that the medicine in main body is selectively worked and controlled to solid carcinoma and metastatic carcinoma including hyaluronic acid or its salt, alkaline-earth metal ions, biodegradable polymer and anticancer agent not soluble in water. Millimicro particle includes hyaluronic acid or its sa Divalent or trivalent transition metal ion or alkaline-earth metal ions; Biodegradable polymer not soluble in water; The useful dosage for the treatment of ground anticancer agent. Nano particles have 10-1, the average particle size of 000 nm.