IN VITRO METHOD OF CULTURING ADIPOSE-DERIVED STROMAL CELLS FOR CARDIOMYOGENIC DIFFERENTIATION

摘要

The present invention relates to an in vitro culture method for differentiating adipose derived stromal cells into cardiomyocytes. More specifically, the present invention provides a method for culturing fat-derived stromal cells comprising adding TGF-β1 to adipocyte-derived stromal cells in vitro and differentiating them into cardiomyocytes and myocardium derived from fat-derived stromal cells differentiated by the method. It is about a cell population.;The culture method and the myocardial cell population according to the present invention increase the practicality of ADSCs as a transplant cell therapy that can be used for the treatment of myocardial infarction, and are useful for the production of such therapeutic agents. Pre-differentiation of ADSCs into cardiomyocytes using this method prior to transplantation is useful for improving the effect of treating myocardial infarction.;Adipose-derived stromal cells, Adipose-derived stem cells, Cardiomyocyte differentiation, TGF