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QUINOXALINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF HAVING MCH1R INHIBITORY ACTIVITY, PROCESS FOR PREPARATION AND USE THEREOF FOR TREATING OBESITY
QUINOXALINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF HAVING MCH1R INHIBITORY ACTIVITY, PROCESS FOR PREPARATION AND USE THEREOF FOR TREATING OBESITY
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机译:具有MCH1R抑制活性的喹喔啉衍生物及其药物可接受的盐,其制备方法及用于治疗肥胖的方法
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摘要
A quinoxaline derivatives having activity of suppressing melanin-concentrating hormone 1 receptor (MCH1R) is provided to treat diseases related to obesity caused by the activation of MCH1R. A quinoxaline derivative of the chemical formula 1 has the activation of suppressing a melanin-concentrating hormone receptor (MCH1R). A method for manufacturing the quinoxaline derivative of the chemical formula 1 comprises: a first step of condensing a compound of the chemical formula 3 with 2-chloro-6-nitroquinoxaline compound of the chemical formula 2 to produce a 6-nitroquinoxaline derivative of the chemical formula 4; a second step of reducing the 6-nitroquinoxaline derivative of the chemical formula 4 to produce a 6-aminoquinoxaline derivative of the chemical formula 5; and a third step of condensing biphenyl-4-carboxylic acid compound of the chemical formula 6 with the aminoquinoxaline derivative of the chemical formula 5 to a quinoxaline derivative which 6-(biphenyl-4-carboxamido) group is substituted.
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