TRP-RICH MODEL ANTIMICROBIAL PEPTIDES AND THEIR ANALOGUES WITH UNNATURAL AMINO ACIDS AND USES THEREOF

摘要

A model type antibiotic peptide to have abundant tryptophan is provided to show very low hemolytic activity in human RBC, to show very high bacterial cell specificity, to show high stability to human serum and to be usefully used as halogen free antimicrobial agent, food antiseptic and make-up additive. A synthesis or recombining antimicrobial peptide is selected from a group consisting of i) peptide selected from a group consisting of sequence number 1 to 4, ii) peptide in which lysine(Lys) is substituted for ornithine(Orn) from the peptide of i), iii) peptide in which leucine(Leu) is substituted for deer leucine(Nle) from the peptide of i) and iv) enantiomer peptide substituted for D-type amino acid corresponding all amino acids from the peptide of i) to iii). The peptide of ii) is written as sequence number 5.