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DRUG DELIVERY SYSTEM FOR ZERO ORDER, ZERO ORDER-BIPHASIC, ASCENDING OR DESCENDING DRUG DELIVERY

机译:零级,双级零级,上升或下降药物输送的药物输送系统

摘要

The invention is directed to a drug delivery device for controlled release of a drug, comprising a core that has a cylindrical plug embedded therein; and a coating that at least partially surrounds the core. The core is comprised of a drug and excipients. The coating surrounding the core is essentially impermeable to the drug. The cylindrical plug, which is embedded in the core, may be hollow or solid. The drug delivery device enables zero-order drug release profiles as well as more complicated release profiles to be obtained. The invention is also directed to a method of making the drug delivery device.
机译:本发明涉及一种用于药物的受控释放的药物输送装置,其包括芯,该芯具有嵌入其中的圆柱形塞子。涂层至少部分地包围芯。核心由药物和赋形剂组成。核心周围的涂层基本上是药物不可渗透的。嵌入芯中的圆柱形插头可以是空心的或实心的。药物输送装置使得能够获得零级药物释放曲线以及更复杂的释放曲线。本发明还涉及一种制造药物输送装置的方法。

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