Aminoalcohol derivatives, preparation method the reof, and pharmaceutical composition for the prevention and treatment of TNF-? mediated diseases containig as an active ingredient thereof

摘要

The invention β- amino alcohol derivatives, production method thereof, and relates to a pharmaceutical composition for preventing and treating TNF-α mediated diseases containing the same as an active ingredient, a β- amino alcohol derivatives of the present invention or their pharmaceutically enemy acceptable salt thereof is tumor necrosis factor-alpha (tumor necrosis factor-α; TNF-α) secretion effectively suppressed, so the invention of β-amino alcohol derivative of the active ingredient as-containing composition is TNF-α-mediated diseases It can be useful as a preventive and therapeutic agent. ; [Formula 1] ; _{(Wherein, R 1, R 2, R} 3, X, Y, m, n , and It is as defined in the specification.) ; β- amino alcohol derivative, tumor necrosis factor-alpha, TNF-α mediated diseases