2-METHYL-2'-HYDROXYMETHYL-6-AMIDO BENZOPYRANS DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PHARMACEUTICAL COMPOSITION FOR TREATING DEMENTIA AND BRAIN STROKE

摘要

This invention relates to 2-methyl-2'-hydroxy-6-amido acceptable benzopyran derivatives and pharmaceutical salts thereof represented by the general formula (1), a method of manufacturing, for the oxidative stress inhibition containing them as an active ingredient It relates to a composition and pharmacological purposes using the same. ; Antioxidant search results for 2-methyl-2'-hydroxy-6-amido-benzopyran derivatives of the present invention, by showing a higher antioxidant activity than conventional antioxidant, wherein the 2-methyl-2'-hydroxymethyl- 6-amido-benzopyran derivative or pharmaceutically acceptable salt thereof, containing as an active ingredient, and provides a composition for inhibiting oxidative stress as possible dose to a biological system, and further, the composition for inhibiting the oxidative stress by decreasing oxidative stress Since expression of the brain cell death inhibition, it can be applied to the pharmacological use as therapeutic agents of dementia and stroke. ; (Wherein, R ₁ and Y are as defined in the specification.) ; Benzopyran-6-amido, combinatorial chemistry, high-speed drug discovery, antioxidants