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COMPLEX MEDICINAL FORM OF INHIBITOR 3-HYDROXY-3-3METHYLGLUTARIL-CoA-REDUCTASE AND HYPOTENSIVE PRODUCT AND METHOD FOR PRODUCING IT
COMPLEX MEDICINAL FORM OF INHIBITOR 3-HYDROXY-3-3METHYLGLUTARIL-CoA-REDUCTASE AND HYPOTENSIVE PRODUCT AND METHOD FOR PRODUCING IT
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机译:抑制剂3-羟基-3-3甲基谷氨酸-CoA-还原酶和降压药的复方药物形式及其生产方法
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摘要
A complex formulation for oral administration comprising a sustained release formulation of an HMG-CoA reductase inhibitor and a film layer for rapid release of an anti-hypertensive agent, the film layer being coated on the sustained release formulation, can achieve improved therapeutic effects of the anti-hypertensive agent by promptly releasing it, while maintaining a constant drug level of the HMG-CoA reductase inhibitor in blood through a slow release. Accordingly, the complex formulation is useful for preventing and treating diseases such as hyperlipidemia, atherosclerosis, hypertension and cardiovascular disease.
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