APPLICATION OF FUMARIC ACID DERIVATIVES FOR THE TREATMENT OF CARDIAC FAILURE, MYOCARDIAL INFARCTION AND angina pectoris

摘要

1. The use of derivatives of fumaric acid selected from the group consisting of dialkyl fumarates, monoalkyl hydrofumarates, salts of monoalkyl esters of fumaric acid, monoamides of fumaric acid, salts of monoamides of fumaric acid, diamides of fumaric acid, monoalkyl monoamido fumarate and carboxylic acid oligomeric mixtures of carbohydrates, medicines for the treatment or prevention of heart failure, especially left ventricular failure, inf rkta infarction and angina pectoris. ! 2. The use according to claim 1, where the fumaric acid derivative is selected from one or more dialkyl esters of fumaric acid of the formula I! ! where R1 and R2, which may be the same or different, independently represent a linear, branched or cyclic, saturated or unsaturated C1-24 alkyl radical or a C5-20 aryl radical, and where these radicals may optionally be substituted with halogen (F, Cl, Br , I) hydroxy, C1-4 alkoxy, C1-4 alkyl, nitro or cyano. ! 3. The use according to claim 1, where the fumaric acid derivative is selected from one or more monoalkyl esters of fumaric acid of formula II! ! where R1 represents a linear, branched or cyclic, saturated or unsaturated C1-24 alkyl radical or a C5-20 aryl radical; ! A is hydrogen, an alkali or alkaline earth metal cation, or a physiologically acceptable transition metal cation, preferably selected from Li +, Na +, K +, Mg2 +, Ca2 +, Zn2 +, Fe2 +, and Mn2 +, and! n is 1 or 2 and corresponds to valency A.! 4. The use of claim 2, wherein the fumaric acid derivative is selected from one or more compounds