NEW THIAZOLE-, TRIAZOLE- OR OXADIAZOLE-CONTAINING TETRACYCLIC COMPOUNDS

摘要

1. The compound of formula I:! ! where R1 is selected from unsubstituted alkyl and unsubstituted aralkyl or heteroaralkyl; ! R2 is selected from hydrogen, unsubstituted alkyl, unsubstituted alkoxy and halogen; and Q is selected from substituted thiazolyl, triazolyl and oxadiazolyl,! or a pharmaceutically acceptable salt thereof. ! 2. The compound according to claim 1, in which R2 is selected from hydrogen, unsubstituted C1-C8 alkyl, unsubstituted C1-C8 alkoxy and halogen. ! 3. The compound according to claim 2, in which R2 is selected from hydrogen, unsubstituted C1-C4 alkyl, unsubstituted C1-C4 alkoxy and halogen. ! 4. The compound according to claim 3, in which R2 is selected from hydrogen, methyl, methoxy, fluorine and chlorine. ! 5. The compound according to any one of claims 1 to 4, in which R1 is selected from unsubstituted C1-C8 alkyl and unsubstituted C1-C8 aralkyl or heteroaralkyl. ! 6. The compound according to claim 5, in which R1 is selected from unsubstituted C1-C4 alkyl and unsubstituted C1-C4 aralkyl or heteroaralkyl. ! 7. The compound according to claim 6, in which R1 is selected from methyl and benzyl. ! 8. The compound according to any one of claims 1 to 7, in which Q is selected from thiazol-2-yl, 1,2,4-triazol-3-yl, 5-thioxo-4,5-dihydro-1H-1,2 , 4-triazol-3-yl and 1,2,4-oxadiazol-3-yl. ! 9. The compound of claim 8, in which Q is thiazol-2-yl, 1,2,4-triazol-3-yl, 5-thioxo-4,5-dihydro-1H-1,2,4-triazole -3-yl or 1,2,4-oxadiazol-3-yl substituted with a group selected from unsubstituted C1-C8 alkyl and unsubstituted aryl or heteroaryl. ! 10. The compound according to claim 9, in which Q is thiazol-2-yl, 1,2,4-triazol-3-yl, 5-thioxo-4,5-dihydro-1H-1,2,4-triazole -3-yl or 1,2,4-oxadiazol-3-yl substituted with a group selected from unsubstituted C1-C4 alkyl and unsubstituted aryl or heteroaryl. ! 11. The compound of claim 10, in which Q is thiazol-2-yl, 1,2,4-triazol-3-yl, 5-thioxo-4,5-dihydro-1H-1,2,4-triazole -3-yl or 1,2,4-ox