APPLICATION OF PYRIMIDILAMINOBENZAMIDE DERIVATIVES FOR TREATMENT OF SYSTEMIC MASTOCYTOSIS

摘要

1. APPLICATION OF THE FORMULA (I) PYRIMIDILAMINOBENZAMIDE DERIVATIVES:! ! WHERE! R1 means hydrogen, (LOW) ALKYL, (LOW) ALKOXY (LOW) ALKYL, Acyloxy (LOW) ALKYL, CARBOXY (LOW.) ALKYL, (LOW.) ALKOXYRBENLENEIS, (LOW.) LOW. ) ALKYL; ! R2 is hydrogen, (lower). Alkyl optionally substituted by one or more identical or different substituents R3, cycloalkyl, benzocycloalkyl, heterocyclyl, an aryl group, or a mono- or bicyclic heteroaryl group, free from or containing one, two or three nitrogen atoms in CYCLE AND NOT CONTAINING OR CONTAINING ONE ATOMIC OF OXYGEN AND CONTAINING OR CONTAINING ONE ATOMIC OF SULFUR, AND THESE SPECIFIED GROUPS IN EACH CASE ARE UNINTERRUPTED OR LOST; ! AND R3 means hydroxy, (lower) alkoxy, acyloxy, carboxy, lower alkoxycarbonyl, carbamoyl, N-mono or N, carbamoyl, aminomino mononomycone, or a mono- or bicyclic heteroaryl group, free from or containing one, two or three nitrogen atoms in the ring and whether or not containing one atom of oxygen and free of the OR containing one sulfur atom, which groups in each case are unsubstituted, mono- or polysubstituted; ! OR WHERE R1 AND R2 TOGETHER MEAN ALKYLENE CONTAINING FOUR, FOUR OR SIX CARBON ATOMS, OPTIONAL MONO OR DISINFECTED BY GROUPS: (LOW), ALKYL, CYCLOELXYLOXYLOXYLENXYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLCOLCYLOROKYLOLLINO and PHILOILOKILOILKOILKYLOILOILKYLOLCYLCOLCYLOLCYLCOLCYLOLCYLCOLCYLOLCYLNOLCYLOILOLCYLOLCYLNOLCYLOILOILNOLCOILOILOILKYLOILOILKOIL DESIGNATED AMINO, OXO, Pyridyl, Pyrazinyl or Pyrimidinyl; MEAN BENZALKYLENE CONTAINING FOUR OR FIVE CARBON ATOMS, OXAALKYLENE CONTAINING ONE OXYGEN ATOM AND THREE OR THO