PHOENOXYUACIC ACIDS AS ACTIVATORS OF DELIVERY PPAR RECEPTORS

摘要

1. The compound of formula I! ! or a pharmaceutically acceptable salt thereof,! where X is selected from O, S, OCH2, and SCH2; ! X1 represents O or S; ! R1 is selected from H, C1-8 alkyl, C2-8 alkenyl, aryl, heteroaryl, C3-10 cycloalkyl and heterocyclyl, where each R1 group is substituted with 0-4 R1a; ! R1a in each case is selected from S, substituted 0-1 R1b, O, substituted 0-1 R1b, halogen, NH2, substituted 0-2 R1b, —CN, NO2, C1-6 alkyl, substituted 0-3 R1b, C2-6 alkenyl substituted 0-2 R1b, C2-6 alkynyl, substituted 0-2 R1b, aryl substituted 0-2 R1b, heteroaryl substituted 0-2 R1b, C3-10 cycloalkyl substituted 0-2 R1b, and heterocycle substituted 0-2 R1b; ! R1b in each case is selected from S, substituted 0-1 R1c, O, substituted 0-1 R1c, halogen, methanesulfonyl, NH2, substituted 0-2 R1c, —CN, NO2, C1-6 alkyl, substituted 0-3 R1c, C2 -6 alkenyl substituted with 0-2 R1c, aryl substituted with 0-2 R1c, heteroaryl substituted with 0-2 R1c, C3-10 cycloalkyl substituted with 0-2 R1c, and heterocycle substituted with 0-2 R1c; ! R1c in each case is selected from S, substituted 0-1 R1d, O, substituted 0-1 R1d, halogen, NH2, substituted 0-2 Rd, —CN, NO2, C1-6 alkyl, substituted 0-2 Rd, C2-6 alkenyl substituted 0-2 R1d aryl; substituted 0-2 R1d; heteroaryl; substituted 0-2 R1d; C3-10 cycloalkyl; substituted 0-2 R1d; and a heterocycle substituted 0-2 R1d; ! R1d in each case is selected from OH, SH, S, O, halogen, NH2, —CN, NO2, C1-6 alkyl, C2-6 alkenyl, aryl, CF3 and OCF3; ! R2 is selected from -C≡C-R2a, -CH = CH-R2a, aryl substituted with 0-3 R2a, and heteroaryl substituted with 0-3 R2a; ! R2a in each case is selected from S, substituted 0-1 R2b, O, substituted 0-1 R2b, halogen, NH2, substituted 0-2 R2b, —CN, NO2, C1-6 alkyl, substituted 0-2 R2b, C2-6 alkenyl substituted 0-2 R2b; aryl substituted 0-2 R2b; heteroaryl substituted 0-2 R2b; C3-10 cycloalkyl substituted 0-2 R2b; and heterocycle substituted 0-2; ! R2b in each case is selected from S substituted by 0-1 R2c,