Substituted 1,2,3,4-tetrahydro-1H-pyrido 4,3-b indoles and 1,2,3,4,5,6-hexahydro-azepino 4,3-b indol-drug substances, pharmaceutical compositions, methods for their preparation and use for treating neurodegenerative diseases and cognitive disorders

摘要

1. Medicinal substance possessing neurotrophic activity of the α-adrenoceptors, dopamine D serotonin receptors and CNS general formula 1 in the form of the free base (or acid) or in the form of pharmaceutically acceptable salts and / or hydrates, for pharmaceutical compositions and dosage forms intended for the treatment and / or prevention of neurodegenerative diseases and cognitive disorders. ! ! wherein R1 is an amino substituent, including a hydrogen atom, an optionally substituted C1-C4 alkyl, acyl, alkoxy, heterocyclyl, substituted sulfonyl; ! R2 represents a substituent of cyclic system, including a hydrogen atom, a halogen atom, an optionally substituted C1-C4 alkyl, CF3, CN, alkoxy, alkoxycarbonyl, carboxyl, heterocyclyl or substituted sulfonyl; ! Ar represents optionally substituted aryl or optionally substituted heterocyclyl; ! Alk represents an optionally substituted C1-S3alkandiil, C2-S3alkendiil, C2-S4alkindiil or SO2 group; ! n = 1 or 2; ! solid line with its accompanying a broken line () represents a single or double bond. ! 2. Drug Substance according to claim 1, characterized in that the spectrum of receptor-specific agonsticheskoy and / or antagonistic activity includes activity to α1A, α1B, α1D, α2A adrenoceptors, dopamine D1, D2L, D2S, D3 and D4.2 receptors and serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. ! 3. Medicinal substance according to claim 1, characterized in that the spectrum of receptor-specific agonistic and / or antagonistic activity can also include some other receptors such as histamine H1,