ORAL DOSED FORMS OF O-DESMETHYLVENENLAFXIN SUCCINATE OF INCREASED BIOAVAILABILITY WITH DELAYED DELIVERY

摘要

1. The composition containing O-desmethylvenlafaxine succinate (DIC) increased bioavailability, and the composition is characterized by delayed release and includes a core containing at least DIC and a water-insoluble excipient, in an oral unit dosage form characterized by a delayed release for at least one hour and sustained release over many hours while ensuring the complete release of more than about 85% of the active ingredient over a period of about 12 to 14 hours! 2. A composition containing DIC of increased bioavailability according to claim 1, characterized by a delayed release for at least two hours and the complete release of more than about 95% of the active ingredient for from about 12 to about 14 hours! 3. A composition containing ICE of increased bioavailability according to claim 1 or 2, characterized in that the above oral dosage unit form further comprises a controlled release coating containing ethyl cellulose. ! 4. A composition containing ICE of increased bioavailability, according to claim 3, characterized in that the above controlled release coating additionally contains about 10% by weight of hypomellose, relative to the weight of the controlled release coating. ! 5. The composition containing ICE of increased bioavailability, according to claim 3, characterized in that the above controlled release coating contains about 90% by weight of a dispersion of ethyl cellulose, relative to the weight of the coating with controlled release. ! 6. The composition containing the internal combustion engine of high bioavailability, according to claim 3, characterized in that the above coating with controlled