Molecular conjugates of synthetic analogues LYULIBERINA and its use as a means of delivering DNA into the cells of the hormone-sensitive tumor (optional)

摘要

FIELD: pharmacology.;SUBSTANCE: invention refers to medicine and can be used as an effective remedy for precise delivery of DNA complexes with molecular conjugates to certain organs and tissues in mammals. The technical effect is ensured by introduction of modified nuclear localisation signal (NLS) that shall allow for conjugates to form complexes with plasmid DNA containing a suicidal gene, and also shall provide higher conjugate concentration in tumour cell nuclei that leads to intensification of cytotoxic properties of doxorubicine.;EFFECT: higher effectiveness of tumour cell exposure.;3 cl, 5 dwg, 6 ex