NEW PYRIMIDINE DERIVATIVES AND THEIR APPLICATION IN THERAPY, AND ALSO APPLICATION OF PYRIMIDINE DERIVATIVES IN THE PRODUCTION OF A MEDICINE FOR THE PREVENTION AND / OR TREATMENT OF ALZHEIMER'S DISEASE

摘要

1. The use of the compounds of formula I:! ! where R1 is selected from hydrogen, halogen, cyano, NO2, C1-3 alkyl, C1-3 haloalkyl, ORa, SO2NRbRc, C0-2alkylC (O) NRbRc, C1-4alkylNRbRc, CH2ORh, SO2Ri, C (O) ORa, CH (OH ) Rj and C (O) Rj; ! R2 and R4 are independently selected from hydrogen, halogen, cyano, NO2, C1-4 alkyl, C1-3 haloalkyl, ORa, SO2NRbRc, C (O) NRbRc, CH2NRbRc, CH2ORh, SO2Ri, C (O) ORa and C (O) Rj ; or ! R1 and R2 together with the atoms to which they are attached are connected to form a 5- or 6-membered heterocyclic ring containing at least one N, O or S, moreover, any of the hydrogen atoms of the CH2 groups in the specified heterocyclic ring can be replaced by oxo , hydroxy or halogen, and any sulfur atom in said heterocyclic ring is optionally oxidized to —SO2—; ! R3 and R5 are independently selected from hydrogen, halo, cyano, C1-3 alkyl, C1-3 haloalkyl, and ORa; ! R6 is selected from CH3 and C6 alkyl, C6 alkenyl, C6 alkynyl and C6 haloalkyl; or ! R6 is a 6 membered heterocyclic ring containing one or more heteroatoms selected from N, O or S, which is optionally substituted with one or more C1-3 alkyl or C1-3 haloalkyl, which are optionally further substituted with one or more C1 -3 alkoxy; ! R7 is selected from hydrogen, C1-3 alkyl, cyano and C1-3 haloalkyl, where indicated! C1-3 alkyl or C1-3 haloalkyl is optionally substituted with one or more than one ORa; ! R8 and R9 are independently selected from hydrogen, cyano and halogen; ! Ra is selected from hydrogen, C1-3 alkyl and C1-3 haloalkyl, wherein said C1-3 alkyl or C1-3 haloalkyl is optionally substituted with one or more C1-3 alkoxy; ! Rb and Rc are independently selected from hydrogen, C1-6 alkyl, heterocyclyl, aryl, heteroaryl, and C1-6 haloalkyl, wherein said C1-6 alkyl, heterocyclyl, aryl, heteroaryl, or C1-6 gal