HISTAMINE RECEPTOR BLOCKERS FOR PHARMACEUTICAL COMPOSITIONS OF ANTIALLERGIC AND AUTOIMMUNE EFFECT

摘要

FIELD: chemistry.;SUBSTANCE: invention concerns new histamine receptor blockers in the form of 2,3,4,5-tetrahydro-1H-pyrido-[3,4-b]indoles of the general formula 1 , where: R¹ is an aminogroup substitute selected out of optionally substituted C₁-C₅alkyl; R²_i is one or several same or different substitutes selected out of hydrogen, halogen, C₁-C₃ alkyl, CF₃; Ar is phenyl or 5-6-member heterocycle containing 1-2 nitrogen or sulphur atoms in the cycle, unsubstituted or substituted by halogen, C₁-C₅alkyl, C₁-C₅alkoxy, substituted aminogroup or trifluormethyl; W is CH₂ group optionally substituted CH₂CH₂ group or optionally substituted CH=CH group.;EFFECT: enhanced antiallergic and autoimmune effect.;4 tbl