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MEDICINE FORMING CELLULAR IMMUNITY FOR MYCOBACTERIUM TUBERCULOSIS H37 Rv, METHOD OF PRODUCTION THEREOF (VERSIONS), RECOMBINANT STRAIN AND TUBERCULOSIS DIAGNOSTIC AGENT
MEDICINE FORMING CELLULAR IMMUNITY FOR MYCOBACTERIUM TUBERCULOSIS H37 Rv, METHOD OF PRODUCTION THEREOF (VERSIONS), RECOMBINANT STRAIN AND TUBERCULOSIS DIAGNOSTIC AGENT
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机译：结核分枝杆菌H37 Rv的形成细胞免疫的药物，其生产方法（版本），重组菌株和结核菌诊断剂
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摘要
FIELD: medicine.;SUBSTANCE: recombinant strain 2-9XL Acinetobacter johnsonii as a part of chromosome contains fragments of chromosomal DNA Mycobacterium tuberculosis H37 Rv and ensures simultaneous synthesis of several proteins forming stabile species-specific tuberculosis glycoprotein complex (Tb-antigen) in outer membrane and capsuliferous bacteria substance. Production method of specified Tb-antigen provides use as producer of recombinant strain 2-9XL Acinetobacter johnsonii using standard mediums, cost-effective safe practice for separation and purification of tuberculosis complex o molecular weight within 55.0 to 75.0 kDa and carbohydrate availability within 20 to 50%. Produced Tb-antigen is used to receive agents forming B- and T-cellular immunity for M tuberculosis H37 Rv and tuberculosis diagnostics.;EFFECT: recombinant strain under invention is perspective producer of specified medicine providing synthesis stability of species-specific tuberculosis complex.;5 cl, 14 dwg, 1 tbl, 4 ex
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机译：领域：医学;实体：重组菌株2-9XL约翰逊不动杆菌作为染色体的一部分，包含染色体DNA结核分枝杆菌H37 Rv的片段，并确保同时合成几种蛋白质，这些蛋白质在外部形成稳定物种特异性结核糖蛋白复合物（Tb-抗原）膜和荚膜细菌的物质。特定Tb抗原的生产方法可作为重组菌株2-9XL约翰逊不动杆菌的生产者，使用标准培养基，经济有效的安全实践来分离和纯化分子量在55.0至75.0 kDa之间的结核病复合体，碳水化合物可利用量在20至50之间％。产生的Tb抗原用于接受针对结核分枝杆菌H37 Rv和结核病诊断形成B细胞和T细胞免疫的药物。效果：本发明的重组菌株是特定药物的透视生产者，提供了物种特异性结核病复合物的合成稳定性。 5 cl，14 dwg，1 tbl，4 ex
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