首页> 外国专利> 1,2,4OXADIAZOLES (VERSIONS), METHODS OF OBTAINING THEM, PHARMACEUTICAL COMPOSITION AND METOD OF INHIBITING ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS - 5

1,2,4OXADIAZOLES (VERSIONS), METHODS OF OBTAINING THEM, PHARMACEUTICAL COMPOSITION AND METOD OF INHIBITING ACTIVATION OF METABOTROPIC GLUTAMATE RECEPTORS - 5

机译：[1,2,4]草二唑（版本），其获得方法，药物组成和抑制代谢的谷氨酸受体的活化-5

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FIELD: chemistry.;SUBSTANCE: described is novel compound of formula (I) ; or its pharmaceutically acceptable salt, values of radicals are given in invention formula Compound has ability to inhibit receptor mGluR5, which intends it for prevention and/or treatment of receptor mGluR5- associated disturbances. Also described is pharmaceutical composition, method of inhibiting activation of receptors mGluR5, using compound of formula (I). Described is method of obtaining compound of formula 1a or 1b structure.;EFFECT: increasing output of suitable product.;18 cl, 825 ex

机译：领域：化学。;物质：描述的是式（I）的新型化合物<图像文件=“ 00000390.GIF” he =“ 39” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 113” /> <图像文件=“ 00000391.GIF” he =“ 19” imgContent =“未定义” imgFormat =“ GIF” wi =“ 85” />; 或其药学上可接受的盐，基团的值在发明式中给出化合物具有抑制的能力受体mGluR5，旨在预防和/或治疗与受体mGluR5相关的疾病。还描述了药物组合物，使用式（I）的化合物抑制受体mGluR5活化的方法。描述了获得式1a或1b结构的化合物的方法。效果：增加合适产物的产量。18 cl，825 ex

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公开/公告号RU2352568C2

专利类型
公开/公告日2009-04-20

原文格式PDF
申请/专利权人 ASTRAZENEKA AB;
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申请/专利号RU20050106844
发明设计人 ARORA DZHALAJ (CA);VALDMAN MAGNUS (SE);VENSBO DAVID (SE);INGVE ULRIKA (SE);ISAAK METVIN (CA);JOKHANSSON MARTIN (SE);JJUBAKK KHELENA (SE);KERS ANIKA (SE);MAKLED DONALD EH. (US);MALBERG JOKHAN (SE);MINIDIS ALEKSANDER (SE);OSKARSSON KARIN (SE);OSTERVALL KRISTOFFER (SE);SIN TAO (CA);SLASSI ABDELMALIK (CA);STEFANATS TOMISLAV (CA);STORMEHN TOMAS M. (US);EHDVARDS LUIZA (CA);
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申请日2003-08-08
分类号C07D413/12;C07D413/14;C07D417/14;C07D471/04;A61K31/4245;A61K31/421;A61K31/42;A61P25;
国家 RU
入库时间 2022-08-21 19:10:35

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