PYRAZOLE DERIVATIEVES, MEDICAL COMPOSITIONS, CONTAINING SAID DERIVATIVES, THEIR APPLICATION IN MEDICINE AND INTERMEDIATE COMPOUNDS FOR THEIR OBTAINING

摘要

FIELD: pharmacology.;SUBSTANCE: claimed invention relates to pyrazole derivatives, which are represented by general formula (I), as well as theirpharmacologically acceptable salts, which have inhibiting activity against human SGLT1, to pharmacological composition, inhibitor of human SGLT1 and based on them medications, to their application for producing pharmacologic composition and to intermediate compounds for their obtaining. where R¹ represents H, hydroxy(C_2-6)alkyl group, one of Q and T represents group, which is presented by general formula: or group, which is presented by general formula while another presents C_1-6alkyl group; R² represents hydrogen atom, C_1-6alkyl group or group of formula: -A-R⁸, where A represents oxygen atom, and R⁸ represents C₆hetherocycloalkyl group, containing oxygen atom as heteroatom; X represents simple bond or oxygen atom, Y represents C_1-6alkylene group or C_2-6alkylene group; Z represents carbonyl group or sulphonyl group; R⁴ and R⁵ are similar or different, and each represents hydrogen atom or C_1-6alkyl group, which can have similar or different 1-3 substituents, selected from substituents (i) Values of sunstituents (i) are iven in invention formula.;EFFECT: obtaining of pyrazole derivatives and based on them medications.;28 cl, 3 tbl, 197 ex