METHOD FOR PREPARATION OF PERINDOPRIL WITH USAGE OF TETRAMETHYL-URONIUM SALTS AS REAGENT OF COUPLING REACTION

摘要

FIELD: chemistry.;SUBSTANCE: invention refers to the selective method for preparation of "АХЭ" inhibitor - perindopril with usage as initial reagent of the sterospecific amino acid N-/1-(S)-ethoxycarbonylbutyl/-(S)-alanine which is activated by tetramethyl-uronium salts in the presence of tertiary organic base and following interreaction with (2S,3aS,7aS)-octahydroindolo-2-carbonic acid or its ester. After completing of the reaction the protective group is removed by the hydrogenation, interphase hydrogenation or extraction.;EFFECT: obtaining of perindopril with usage of tetramethyl-uronium salts as reagents of coupling reaction.;5 cl, 3 ex