Native sponge collagen, process for its isolation and its use, as well as native nanoparticulate sponge collagen, process for its preparation and its use

摘要

Isolation of sponge collagen (I) involves placing the starting material in alcohol, washing, treating with an extractant and working up the obtained collagen extract. An independent claim is also included for the preparation of nanoparticulate collagen (II) by dispersing and homogenizing a starting collagen material, emulsifying, crosslinking using an excess of crosslinking agent and working up. - ACTIVITY : Antiinflammatory; Antiarthritic; Antirheumatic; Antigout; Immunosuppressive; Antiasthmatic; Gynecological; Antipsoriatic; Dermatological; Vulnerary; Antiulcer; Vasotropic; Cytostatic; Antipyretic; Antidiabetic; Nephrotropic; Cardiant. Oral administration of collagen isolated from Chondrosia renformis to 10 chronic arthritis patients, at 5 g three times daily for 4 weeks, significantly reduced joint pain and facilitated movement in all cases. - MECHANISM OF ACTION : Cyclooxygenase Inhibitor; Antioxidant. Collagen isolated from Chondrosia renformis at a concentration of 3 Microg/ml inhibited lipopolysaccharide-induced of cyclooxygenase in human monocytes by 61%.