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methods for rational mutagenesis of a v beta t cell receptors and corresponding mutant mdm2 protein specific a / beta t cell receptors
methods for rational mutagenesis of a v beta t cell receptors and corresponding mutant mdm2 protein specific a / beta t cell receptors
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机译:vβt细胞受体和相应的突变的mdm2蛋白特异性a /βt细胞受体的合理诱变方法
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摘要
The invention relates to the rational mutagenesis of polypeptides of / T-cell receptors that mediate an oncogen-specific T-cell response, nucleic acids encoding these and their use in the therapy, diagnosis and/or prevention of cancerous diseases. The invention further relates to a T-cell response-mediating MDM2-protein-specific / T-cell receptor, which has been rationally mutated by means of the method according to the present invention, and the uses thereof.
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