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DENDRITIC CELLS, ACTIVATED IN THE PRESENCE OF GLUCOCORTICOID HORMONES, ARE ABLE TO PRESS THE ANTIGEN-SPECIFIC T-CELL ANSWER
DENDRITIC CELLS, ACTIVATED IN THE PRESENCE OF GLUCOCORTICOID HORMONES, ARE ABLE TO PRESS THE ANTIGEN-SPECIFIC T-CELL ANSWER
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机译:在糖皮质激素的存在下活化的树突状细胞能够压制抗原特异性T细胞答案
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摘要
The present invention provides novel methods for immunotherapy. The invention provides immune cells and methods to generate them, with the capacity to at least in part reduce an immune response in a host. In one aspect, the invention provides a method for generating a dendritic cell with the capacity to tolerize a T-cell for antigen the T-cell was specific for including culturing peripheral blood monocytes from an individual to differentiate into dendritic cells, activating the dendritic cells in the presence of a glucocorticoid hormone and loading the activated dendritic cell with the antigen the T-cell was specific for.
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