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PROCEDURES FOR THE MANUFACTURE OF 5-A(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-1-HYDROXYETHYLU-8-HYDROXY-(1H)-CHINOLIN-2-ON-SALS, WHICH ARE INCLUDED AS ADRENOZEPTORAGONISTS
PROCEDURES FOR THE MANUFACTURE OF 5-A(R)-2-(5,6-DIETHYL-INDAN-2-YLAMINO)-1-HYDROXYETHYLU-8-HYDROXY-(1H)-CHINOLIN-2-ON-SALS, WHICH ARE INCLUDED AS ADRENOZEPTORAGONISTS
A process for preparing 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8- hydroxy-(1H)-quinolin-2-one salt. The process involves forming an acid salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-substituted oxy-(1H)-quinolin-2-one; and converting the acid salt to a salt of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one without isolating the free base of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-(1H)-quinolin-2-one.
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