compounds of marine origin with calcium channel blocking properties for the treatment of cognitive or neurodegenerative diseases

摘要

The invention provides compounds having two spiro heterocyclic units connected through a linker of a certain length. Some of these compounds have been obtained from Aplysinia sp. The compounds exhibit VDCC blocker activity as well as acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of use in the treatment of brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jacob disease or Gerstmann-Straussler-Scheinher disease.