high relaxivity contrast agent for use in the magnetresonanzbilddarstellung (mri) containing a chelatbildende group with polyhydroxylierten substituents

摘要

The present invention relates to a novel class of paramagnetic ion-based contrast agents of formula (I), wherein a chelating backbone moiety is highly functionalized by the presence of one or more polyhydroxylated chain, that show a pharmacokinetic profile analogous to that of the commonly used T1-general extravascular agents (NSA) but are further characterized by a higher relaxivity.