and prognosis of malignant tumours on the basis of the investigation of metabolic markers of cell

摘要

The invention relates to a method for cancer detection, progression analysis and malign tumour prognosis based on the study of metabolic markers of the cell. The inventive method consists in using the study of the protein expression of the bioenergetic function of the mitochondrion, such as the beta -catalytic subunit of the H+-ATP synthase, in relation to structural proteins and mitochondrial respiration, such as hsp 60 and cytochrome oxidase subunits I and IV respectively, and said mitochondrial bioenergetic index, (ratio of beta -ATPasa/hsp60; beta -ATPasa/COX I; beta -ATPasa/COX IV) which relates to the cellular protein expression of the glycolytic pathway, such as glyceraldehyde-3-phosphate dehydrogenase and pyruvate kinase M, in order to generate the bioenergetic index of the cell.