DRUG FOR CONTROLLING LABOR PAIN AND TREATING PREMATURE BIRTH

摘要

PPROBLEM TO BE SOLVED: To provide an ideal drug for controlling labor pain and treating premature birth which can adjust initiation of labor pain to control the term of delivery, is effective for a patient of premature birth, and does not adversely affect a fetus when administered. PSOLUTION: An expression plasmid is obtained by connecting a cDNA which codes ORF of soluble form of human P-LAP to the Hind III site of a pdKCR-dhfr vector. Then, gene introduction into Chinese hamster ovary(CHO)-dhfr-cells is performed utilizing this expression plasmid. Thereafter, the gene-introduced cells are maintained in an -mineral essential medium, and then a resistant clone is selected, and the resistance clone is multiplied to obtain a predetermined amount of a soluble form of P-LAP. Subsequently, when the obtained P-LAP is administered to a pregnant mouse to count the period between pregnancy and childbirth, it has been found that the administration of P-LAP tends to extend the period of pregnancy. PCOPYRIGHT: (C)2010,JPO&INPIT