METHOD FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-beta-D-ARABINOFURANOSYL)-9H-PURINE-6-AMINE

摘要

PPROBLEM TO BE SOLVED: To provide a method for synthesizing a 2-chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purine-6-amine in a comparatively high yield. PSOLUTION: In the method for synthesizing a 2-chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purine-6-amine, (a) an anion of 2-chloro-6-substituted purine (here, the substituent of the 6-position of the 2-chloro-6-substituted purine is selected from the group consisting of an amino group and a protected amino group) is reacted with protected and activated 2-deoxy-2-fluoro-D-arabinofuranose and then with (b) ammonia to obtain 2-chloro-9-(2-deoxy-2-fluoro--D-arabinofuranosyl)-9H-purine-6-amine. PCOPYRIGHT: (C)2010,JPO&INPIT